NIHB Pharmacist

Focusing on Naloxone, with a bit of Hep C and HIV Coverage

Naloxone (Narcan)

Naloxone allows for the reversal of respiratory depression:

  • Buys time until an ambulance arrives and supportive care can be given; and
  • Decreases risk of anoxic brain injury and death.

Very safe!

  • Has no effect in the absence of opioids
  • Most of the adverse effects are directly related to opioid withdrawal or injection site reaction.

Treatment of Chronic Hepatitis C

Effective March 31st 2017, the Non-Insured Health Benefits (NIHB) Program expanded coverage criteria and added new medications for the treatment of hepatitis C as limited use (LU) benefits:

  • Harvoni (ledipasvir/sofosbuvir)
  • Sovaldi (sofosbuvir)
  • Epclusa (sofosbuvir/velpatasvir)
  • Zepatier (elbasvir/grazoprevir)
  • Daklinza (daclatasvir)
  • Sunvepra (asunaprevir)
  • Ibavyr (ribavirin)

Hep C Coverage Criteria

  • Treatment is prescribed by a hepatologist, gastroenterologist, or infectious disease specialist (or other prescriber experienced in treating patients with chronic hepatitis C); AND
  • Laboratory confirmed hepatitis C genotype 1, 2, 3, 4, 5, 6 or mixed genotype; &
  • Laboratory confirmed quantitative HCV RNA level taken in the last 12 months; &
  • Fibrosis stage of F2 or greater (Metavir scale or equivalent); OR

Fibrosis stage less than F2 AND at least one of the following:

  • Co-infection with human immunodeficiency virus (HIV) or hepatitis B virus
  • Co-existent liver disease with diagnostic evidence of fatty liver disease (Example: nonalcoholic steatohepatitis [NASH])
  • Post organ transplant (may include liver and/or non-liver organ transplant)
  • Extra-hepatic manifestations
  • Chronic kidney disease stage 3, 4 or 5 as defined by National Kidney Foundation Kidney Disease outcomes Quality Initiative (K/DOQI)
  • Diabetic patients receiving treatment with anti-diabetic drugs
  • Women of childbearing age who plan to get pregnant within the next 12 months

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